Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation

Background: Aloin, as a bioactive compound, has variety of pharmacological functions, but its effects on combined allergic rhinitis and asthma syndrome (CARAS) have not been studied. To clarify the protective effect mechanism aloin in treatment CARAS by network pharmacology, molecular dynamics simulation experiment. Methods: The targets aloin, were obtained from various databases. protein interaction was constructed for common targets, docking simulations performed core targets. Functional pathway enrichment analysis also using R software. Varieties biological experiments conducted to verify inflammatory changes regulatory mechanism. Results: A total 42 anti-allergic 58 anti-asthma obtained, 5 6 identified topological analysis. GO KEGG analyses showed that endopeptidase activity MAPK signaling played important roles asthma. Molecular could stably bind target proteins. Experimental verification significantly inhibited expression factors, may regulate down-regulating related Conclusion: This study effect, potential CARAS. It provides reference understanding clinical application ameliorates